@article{122576,
  author = {Orkide Koyuncu and Margaret MacGibeny and Lynn Enquist},
  title = {Latent versus productive infection: the alpha herpesvirus switch},
  abstract = {<p>Alpha herpesviruses are common pathogens of mammals. They establish a productive infection in many cell types, but a life-long latent infection occurs in PNS neurons. A vast majority of the human population has latent HSV-1 infections. Currently, there is no cure to clear latent infections. Even though HSV-1 is among the best studied viral pathogens, regulation of latency and reactivation is not well understood due to several challenges including a lack of animal models that precisely recapitulate latency/reactivation episodes; a difficulty in modeling latency; and a limited understanding of neuronal biology. In this review, we discuss insights gained from latency models with a focus on the neuronal and viral factors that determine the mode of infection.</p>
},
  year = {2018},
  journal = {Future Virol},
  volume = {13},
  pages = {431-443},
  month = {05/2018},
  issn = {1746-0794},
  doi = {10.2217/fvl-2018-0023},
  language = {eng},
}